Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice
N Kiguchi, T Maeda, Y Kobayashi, S Kishioka - Neuroscience letters, 2008 - Elsevier
Chronic treatment with vincristine (VCR) causes mechanical allodynia as an adverse effect.
We previously reported that peripheral macrophage-derived interleukin-6 played a critical
role in VCR-induced allodynia. However, the involvement of glial cell activation and central
sensitization in VCR-induced allodynia is still unclear. In this study, we focused on tumor
necrosis factor-alpha (TNF-α) in spinal cord, and investigated the role of TNF-α in VCR-
induced allodynia in mice. VCR (0.1 mg/kg, ip) was administered to mice once per day for 7 …
We previously reported that peripheral macrophage-derived interleukin-6 played a critical
role in VCR-induced allodynia. However, the involvement of glial cell activation and central
sensitization in VCR-induced allodynia is still unclear. In this study, we focused on tumor
necrosis factor-alpha (TNF-α) in spinal cord, and investigated the role of TNF-α in VCR-
induced allodynia in mice. VCR (0.1 mg/kg, ip) was administered to mice once per day for 7 …
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